CXCL1
GeneName
CXCL1
Summary
CXCL1, also known as GRO or GRO alpha, is an 11 kDa chemokine that is secreted into the extracellular region and plays a pivotal role in mediating immune responses. It is primarily involved in the recruitment of neutrophils to sites of inflammation through its chemotactic properties. CXCL1 interacts with G protein-coupled receptors on target cells, initiating various signalling pathways that contribute to immune cell activation and migration. Additionally, it has roles in actin cytoskeleton organisation and can influence cell proliferation and differentiation within the nervous system.
Importance
CXCL1 is relevant to: - The inflammatory response and immune cell recruitment, making it a target for therapeutic interventions in inflammatory diseases. - Cancer biology, where it may influence tumour progression and metastasis through its effects on the tumour microenvironment. - Neurological research, given its involvement in nervous system development and potential roles in neuroinflammatory conditions. - Understanding the mechanisms of chemotaxis, which is crucial for the development of drugs targeting immune cell trafficking.
Top Products
For researchers investigating CXCL1, we recommend two primary antibodies that stand out for their performance and reliability. The first is the well-cited Anti-CXCL1/GRO alpha antibody [MM0208-9A18] (ab89318), a monoclonal antibody that has garnered 7 citations and is suitable for immunohistochemistry (IHC) and western blotting (WB). This antibody is a trusted choice for those looking to study CXCL1 in various contexts.Additionally, we offer the recombinant antibody, Anti-CXCL1/GRO alpha antibody [EPR19892] (ab206411), which has been validated in knockout models and is ideal for applications such as western blotting (WB) and immunoprecipitation (IP). With 8 citations, this product not only provides the batch-to-batch consistency that recombinant antibodies are known for but also enhances the versatility of your research on CXCL1. The Human CXCL1 ELISA Kit (GRO alpha) (ab190805), supported by 11 citations, is an excellent option for researchers looking to accurately measure CXCL1 levels in their samples.
Abcam Product Citation Summary
The data indicates that the CXCL1 target is being studied in the context of human bone marrow mesenchymal stem cells (h-JBMMSCs). The focus appears to be on gene expression regulation, highlighting the importance of CXCL1 in stem cell biology.
Abcam Product Citation Table
Function
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Post-translational modifications
N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Sequence Similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Cellular localization
- Secreted
Alternative names
GRO, GRO1, GROA, MGSA, SCYB1, CXCL1, Growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha(1-73), Melanoma growth stimulatory activity, Neutrophil-activating protein 3, NAP-3
Database links
swissprot:P09341 entrezGene:2919 omim:155730
Other research areas
- Immuno-oncology
- Neuroscience