CNP
GeneName
CNP
Summary
CNP, also known as CNPase or C type natriuretic peptide, is a 48 kDa protein primarily expressed in the cytoplasm and associated with various cellular components such as the extracellular space, myelin sheath, and synapse. It plays a role in several biological processes including axonogenesis and chemical synaptic transmission. CNP is involved in the catabolism of cyclic nucleotides and is implicated in oligodendrocyte differentiation. Its RNA binding activity suggests a role in post-transcriptional regulation and signal transduction within the nervous system.
Importance
CNP is relevant to: - Neurodevelopmental processes, particularly in the differentiation of oligodendrocytes which are essential for myelination in the central nervous system. - The modulation of synaptic transmission, impacting learning and memory functions. - Responses to neurotoxic substances, which may influence neurodegenerative disease mechanisms. - Adult locomotory behaviour, indicating its potential role in motor control and coordination.
Top Products
For researchers investigating CNP, we recommend two excellent primary antibodies. The first is the highly regarded Anti-CNPase antibody [11-5B] (ab6319), a well-cited monoclonal antibody with 182 citations. This antibody is validated in knockout models and is suitable for a variety of applications, including immunohistochemistry (IHC), western blotting (WB), and immunocytochemistry (ICC), making it a reliable choice for your research needs. Additionally, we offer the recombinant antibody, Anti-CNPase antibody [EPR13005] (ab183500). This product is ideal for those seeking the consistency that recombinant antibodies provide and is validated for use in western blotting (WB) and immunocytochemistry (ICC). With 5 citations, it is gaining traction in the research community. Together, these antibodies provide robust options for studying CNP effectively.
Abcam Product Citation Summary
The data indicates that CNP is a significant marker in studies related to demyelination, remyelination, and oligodendrogenesis, particularly in mouse and rat models. The use of CNP antibodies in various applications such as immunohistochemistry, western blotting, and immunocytochemistry highlights its importance in understanding CNS conditions, including multiple sclerosis and hypomyelination.
Abcam Product Citation Table
Function
Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions (PubMed:38117830).
Acts as an antiviral factor by suppressing the assembly of HIV-1 virions through direct interaction with GAG.
Involvement in disease
Leukodystrophy, hypomyelinating, 20
HLD20
An autosomal recessive disorder characterized by neuroregression and loss of motor, language and cognitive skills, after a normal early development. Disease onset is between 12 and 18 month of age. Patients show poor overall growth, microcephaly, feeding difficulties and spastic quadriplegia. Some patients may have seizures. Death in childhood may occur. Hypomyelinating leukodystrophy with subcortical and periventricular white matter abnormalities is seen on brain imaging.
None
The disease may be caused by variants affecting the gene represented in this entry.
Post-translational modifications
Acetylated. Acetylation suppresses enzymatic activity through restricting substrate accessibility. Deacetylated by SIRT3.
Sequence Similarities
Belongs to the 2H phosphoesterase superfamily. CNPase family.
Cellular localization
- Melanosome
- Mitochondrion
- Firmly bound to membrane structures of brain white matter.
- Isoform CNPI
- Cell membrane
Alternative names
CNP, CNPase