Ccl21c
Function
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
Sequence Similarities
Belongs to the intercrine beta (chemokine CC) family.
Tissue Specificity
Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.
Cellular localization
- Secreted
Alternative names
Scya21c, Ccl21c, C-C motif chemokine 21c, 6Ckine, Beta-chemokine exodus-2, Small-inducible cytokine A21c, Thymus-derived chemotactic agent 4, TCA4