CALCA

Function

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770).

Sequence Similarities

Belongs to the calcitonin family.

Tissue Specificity

Expressed in spinal cord.

Cellular localization

• Secreted

Alternative names

CALC1, CALCA, Calcitonin gene-related peptide 1, CGRP1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I

Database links

swissprot:P06881 omim:114130 omim:114160 swissprot:P10092 entrezGene:796 entrezGene:797