ADAM2
Domain
A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Post-translational modifications
The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
Tissue Specificity
Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
FTNB, ADAM2, Disintegrin and metalloproteinase domain-containing protein 2, ADAM 2, Cancer/testis antigen 15, Fertilin subunit beta, PH-30, PH30-beta, CT15, PH30