製品の概要

  • 製品名

    Tamoxifen citrate, Estrogen receptor antagonist and partial agonist
  • 製品の詳細

    Estrogen receptor antagonist and partial agonist
  • 生理活性の詳細

    Competitive estrogen receptor antagonist and partial agonist. Inhibits estrogen dependent gene transcription and tumor growth. Additionally decreases cardiac infarction and inhibits Kir2.1, Kir2.2 and Kir2.3 potassium channels (IC50 values are 0.93, 0.87 and 0.31 µM, respectively).
  • 精製度

    > 99%
  • CAS 番号

    54965-24-1
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Ponce-Balbuena D  et al. Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions. J Pharmacol Exp Ther 331:563-73 (2009). Read more (PubMed: 19654266) »
  • Massarweh S  et al. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res 68:826-33 (2008). Read more (PubMed: 18245484) »
  • Mandlekar S & Kong AN Mechanisms of tamoxifen-induced apoptosis. Apoptosis 6:469-77 (2001). Read more (PubMed: 11595837) »

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