Key features and details
- Mouse monoclonal [B72.3] to TAG72
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Rat, Hamster, Human
- Isotype: IgG1
製品名Anti-TAG72 antibody [B72.3]
製品の詳細Mouse monoclonal [B72.3] to TAG72
特異性This antibody recognises an oncofetal antigen of >1,000kDa, identified as a Tumor-Associated Glycoprotein (TAG-72) with the properties of a mucin. Weak or no reactivity has been observed with most cell types of normal adult tissue excepting the secretory endometrium.
アプリケーション適用あり: IHC-P, IHC-Frmore details
種交差性交差種: Rat, Hamster, Human
Membrane-enriched fraction of a human breast carcinoma liver metastasis
- Lung carcinoma or breast cancer.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
バッファーConstituents: PBS, Tissue culture supernatant
Proprietary preservative that is not sodium azide or thimerosal, protein carrier.
Concentration information loading...
Our Abpromise guarantee covers the use of ab691 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Incubation for 30-60 minutes at room temperature is recommended.|
|IHC-Fr||Use at an assay dependent concentration.|
関連性The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
- CA 72.4 antibody
- CA72.4 antibody
- TAG 72 antibody
- Tumor associated glycoprotein 72 antibody
ab691 は 14 報の論文で使用されています。
- Persson N et al. Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells. Glycobiology 27:635-645 (2017). PubMed: 28419225
- Tamura F et al. RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells. Gastric Cancer 19:85-97 (2016). PubMed: 25532910
- Xu F et al. Expression profile of mucin-associated sialyl-Tn antigen in Chinese patients with different colorectal lesions (adenomas, carcinomas). Int J Clin Exp Pathol 8:11549-54 (2015). PubMed: 26617889
- van Niekerk CC et al. Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev 21:247-57 (1997). PubMed: 9167042
- Guadagni F et al. TAG-72 expression and its role in the biological evaluation of human colorectal cancer. Anticancer Res 16:2141-8 (1996). PubMed: 8694534