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Anti-Surfactant Protein B (Mature) 抗体 [RM370] (ab271345)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)
  • Western blot - Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)
  • Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [RM370] to Surfactant Protein B (Mature)
  • Suitable for: IHC-P, WB
  • Reacts with: Human

製品の概要

  • 製品名

    Anti-Surfactant Protein B (Mature) antibody [RM370]

  • 製品の詳細

    Rabbit monoclonal [RM370] to Surfactant Protein B (Mature)

  • 由来種

    Rabbit

  • 特異性

    Reacts with human Surfactant Protein B (Mature) and pro-Surfactant Protein B.

  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    WB
    Human
    See all applications and species data

  • 免疫原

    Synthetic peptide corresponding to Human Surfactant Protein B (Mature) (C terminal).
    Database link: P07988

  • ポジティブ･コントロール

    • IHC-P: Human lung cancer tissue WB: Human lung tissue lysate

製品の特性

アプリケーション

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab271345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

アプリケーション Species
IHC-P
Human
WB
Human
アプリケーション Abreviews 特記事項
IHC-P
1/500 - 1/1000.
WB
1/500 - 1/1000. Detects a band of approximately 10 kDa (predicted molecular weight: 42 kDa).
特記事項
IHC-P
1/500 - 1/1000.
WB
1/500 - 1/1000. Detects a band of approximately 10 kDa (predicted molecular weight: 42 kDa).

ターゲット情報

  • 機能

    Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

  • 関連疾患

    Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
    Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:267450]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.

  • 配列類似性

    Contains 1 saposin A-type domain.
    Contains 3 saposin B-type domains.

  • 細胞内局在

    Secreted > extracellular space > surface film.
  • Information by UniProt

  • 参照データベース

    • 別名

      • 18 kDa pulmonary-surfactant protein antibody
      • 6 kDa protein antibody
      • PSPB antibody
      • PSPB_HUMAN antibody
      • Pulmonary surfactant associated protein B 18kD antibody
      • Pulmonary surfactant associated protein B antibody
      • Pulmonary surfactant-associated protein B antibody
      • Pulmonary surfactant-associated proteolipid SPL(Phe) antibody
      • SFTB3 antibody
      • SFTP3 antibody
      • SFTPB antibody
      • SP B antibody
      • SP-B antibody
      • SPB antibody
      • Surfactant pulmonary associated protein B antibody
      see all

    画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)

      Formalin-fixed, paraffin embedded human lung cancer tissue stained for Surfactant Protein B (Mature) using ab271345 at a 1/1000 dilution in immunohistochemical analysis.

    • Western blot - Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)
      Western blot - Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)
      Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345) at 1/1000 dilution + Human lung tissue lysate

      Predicted band size: 42 kDa

    • Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)
      Anti-Surfactant Protein B (Mature) antibody [RM370] (ab271345)

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab271345 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab271345 は論文での使用が確認できていません。

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