製品の概要

  • 製品名

    Suramin hexasodium salt, non-selective P2 purinergic antagonist
  • 製品の詳細

    Non-selective P2 purinergic antagonist
  • 生理活性の詳細

    Non-selective P2 purinergic antagonist (pEC50 values are 4.5 (P2X2), 5.4 (P2X5), 4.3 (P2Y2), 4.0 (P2Y4) and 4.8 (P2Y11)). Displays diverse biological actions. Shows antitumor activity, inhibits binding of multiple growth factors and additionally inhibits glutamatergic synaptic transmission.
  • 精製度

    > 99%
  • CAS 番号

    129-46-4
  • 構造式

    Chemical Structure

製品の特性

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  • Inhibition by suramin, PPADS and DIDS significantly reduces the ATP-induced increase in extracellular H+ flux from isolated Müller cells.

    (A) A representative trace from a single Müller cell shows a significant increase in H+ flux in response to 10 μM ATP that is significantly reduced by the ATP receptor blockers 200 μM PPADS and 200 μM suramin; asterisk indicates a background control reading. (B) 300 μM DIDS, which inhibits anion transport, significantly reduces the increase in H+ flux in response to 10 μM ATP. (C) Mean responses to 10 μM ATP with or without suramin and PPADS in the bath; N = 7, error bars represent SEMs. (D) Mean responses to 10 μM ATP in the presence of 300 μM DIDS (N = 6) and in the absence of DIDS, N = 5 (controls).

参考文献

This product has been referenced in:

  • Taniguti AP  et al. Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-ß1 blocker. Muscle Nerve 43:82-7 (2011). Read more (PubMed: 21108244) »
  • Gever JR  et al. Pharmacology of P2X channels. Pflugers Arch 452:513-37 (2006). Read more (PubMed: 16649055) »
  • Zhuang S & Schnellmann RG Suramin promotes proliferation and scattering of renal epithelial cells. J Pharmacol Exp Ther 314:383-90 (2005). Read more (PubMed: 15833899) »
  • Suzuki E  et al. Divergent effects of the purinoceptor antagonists suramin and pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) (PPNDS) on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Mol Pharmacol 66:1738-47 (2004). Read more (PubMed: 15448189) »
See all 2 Publications for this product

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