Anti-Stathmin 1 抗体 [SP49], prediluted (ab228139)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP49] to Stathmin 1, prediluted
- Suitable for: IHC-P
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-Stathmin 1 antibody [SP49], prediluted
Stathmin 1 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [SP49] to Stathmin 1, prediluted -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Chicken, Cow, Dog, Pig -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ・コントロール
- IHC-P: Human tonsil, B-cell lymphoma, thymus, reactive lymph node, HK lymphoma, melanoma, cervical squamous cell carcinoma, breast ductal cell carcinoma, colon adenocarcinoma, ovarian adenocarcinoma, pancreatic adenocarcinoma, endometrium adenocarcinoma, stomach adenocarcinoma and bladder transitional cell carcinoma tissue.
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特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Do Not Freeze. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: Tris buffered saline, 1% BSA -
Concentration information loading...
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精製度
Protein A/G purified -
特記事項(精製)
Purified from TCS by protein A/G. -
ポリ/モノ
モノクローナル -
クローン名
SP49 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab228139の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/1. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Pre-diluted / ready to use. |
特記事項 |
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IHC-P
1/1. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Pre-diluted / ready to use. |
ターゲット情報
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機能
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. -
組織特異性
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. -
配列類似性
Belongs to the stathmin family.
Contains 1 SLD (stathmin-like) domain. -
翻訳後修飾
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. -
細胞内局在
Cytoplasm > cytoskeleton. - Information by UniProt
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参照データベース
- Entrez Gene: 616317 Cow
- Entrez Gene: 478175 Dog
- Entrez Gene: 3925 Human
- Entrez Gene: 16765 Mouse
- Entrez Gene: 29332 Rat
- Omim: 151442 Human
- SwissProt: Q3T0C7 Cow
- SwissProt: P16949 Human
see all -
別名
- C1orf215 antibody
- Lag antibody
- LAP 18 antibody
see all
画像
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Formalin-fixed, paraffin-embedded human tonsil tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human B-cell lymphoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human thymus tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human reactive lymph node tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human HK lymphoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human melanoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human cervical squamous cell carcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human breast ductal cell carcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human ovarian adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human pancreatic adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human endometrium adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human stomach adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
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Formalin-fixed, paraffin-embedded human bladder transitional cell carcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab228139 は論文での使用が確認できていません。