製品の概要

  • 製品名

    Spiperone hydrochloride, 5-HT and D2-like receptor antagonist
  • 製品の詳細

    5-HT and D2-like receptor antagonist
  • 生理活性の詳細

    5-HT and D2-like receptor antagonist. (IC50 values are 1.6 and 15 nM at 5-HT2 and 5-HT1C receptors, respectively. Ki values are 0.06 ( D2), 0.6 (D3), 0.08 (D4), ~ 350 (D1) and ~ 3500 nM (D5)). Potently enhances intracellular Ca2+ levels. Additionally activates Ca2+-activated Cl- channels (CaCC) to induce Cl- secretion.
  • 精製度

    > 98%
  • CAS 番号

    2022-29-9
  • 構造式

    Chemical Structure

製品の特性

画像

  • Cabergoline exerted neuroprotective effect via D2 receptor-mediated mechanism.

    (Panel B) Spiperone inhibited neuroprotection by cabergoline. Spiperone (10 µM) was applied 20 mins before cabergoline (10 µM) treatment, followed by MTT assay. The data represent mean ± SD (n = 6–12). ***P<0.001 vs. - H2O2 - Caber - spiperone, †††P<0.001 vs. + H2O2 - Caber - spiperone (three-way ANOVA).

参考文献

This product has been referenced in:

  • Liang L  et al. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am J Physiol Cell Physiol 296:C131-41 (2009). Read more (PubMed: 18987251) »
  • Lu D & Carson DA Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol 9:13 (2009). Read more (PubMed: 19948059) »
  • Woodward RM  et al. Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 89:4708-12 (1992). Read more (PubMed: 1350095) »
See all 2 Publications for this product

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