SP600125, JNK inhibitor (ab120065)
Key features and details
- JNK inhibitor
- CAS Number: 129-56-6
- Soluble in DMSO to 100 mM and in ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SP600125, JNK inhibitor -
製品の詳細
JNK inhibitor -
生理活性の詳細
Potent and selective JNK1, -2, and -3 inhibitor (IC50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
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CAS 番号
129-56-6 -
構造式
製品の特性
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体系名
1,9-Pyrazoloanthrone -
分子量
220.23 -
分子式
C14H8N2O -
PubChem 登録番号
8515 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 5 mM (with heating) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=C4c1cccc2nnc(c12)c3ccccc34 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (39)
ab120065 は 39 報の論文で使用されています。
- Gao S et al. Effects of Holliday Junction-Recognition Protein-Mediated C-Jun N-Terminal Kinase/ Signal Transducer and Activator of Transcription 3 Signaling Pathway on Cell Proliferation, Cell Cycle and Cell Apoptosis in Bladder Urothelial Carcinoma. Tohoku J Exp Med 259:209-219 (2023). PubMed: 36543245
- Zhang L et al. Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect. PLoS Pathog 19:e1011134 (2023). PubMed: 36706154
- Wang G et al. Exenatide exerts a neuroprotective effect against diabetic cognitive impairment in rats by inhibiting apoptosis: Role of the JNK/c-JUN signaling pathway. Mol Med Rep 25:N/A (2022). PubMed: 35119079
- Hu X et al. Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis. Front Physiol 13:823275 (2022). PubMed: 35211032
- Ivshina MP et al. CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia. Glia 70:1850-1863 (2022). PubMed: 35635122