Key features and details
- Rabbit polyclonal to SOCS1
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
SOCS1 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to SOCS1
特異性By Western blot, this antibody detects a band of approximately 24 kDa in GH treated HEK 293 cell lysate, which corresponds to the predicted molecular weight of SOCS 1. However, in human spleen cell lysate a band at 37kDa is observed.
アプリケーション適用あり: WBmore details
種交差性交差種: Mouse, Rat, Human
保存方法Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
バッファーPreservative: 0.02% Sodium azide
Constituents: 0.1% BSA, PBS
Concentration information loading...
精製度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab3691 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 24 kDa).|
機能SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
組織特異性Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
パスウェイProtein modification; protein ubiquitination.
配列類似性Contains 1 SH2 domain.
Contains 1 SOCS box domain.
ドメインThe ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box.
- Information by UniProt
- CISH 1 antibody
- CISH1 antibody
- Cytokine inducible SH2 protein 1 antibody
ab3691 は 24 報の論文で使用されています。
- Wang Y et al. A lipid-soluble extract of Pinellia pedatisecta Schott orchestrates intratumoral dendritic cell-driven immune activation through SOCS1 signaling in cervical cancer. J Ethnopharmacol N/A:112837 (2020). PubMed: 32276009
- Sun XH et al. miR-155 mediates inflammatory injury of hippocampal neuronal cells via the activation of microglia. Mol Med Rep 19:2627-2635 (2019). PubMed: 30720115
- Bullock BL et al. Tumor-intrinsic response to IFN? shapes the tumor microenvironment and anti-PD-1 response in NSCLC. Life Sci Alliance 2:N/A (2019). PubMed: 31133614
- Wang Y et al. A lipid-soluble extract of Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated dendritic cell activation and maturation. J Ethnopharmacol 241:111980 (2019). PubMed: 31146000
- Yoo JY et al. Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. Biol Reprod 95:11 (2016). PubMed: 27226311