SKF 96365, TRP channel blocker (ab120280)

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製品の概要

  • 製品名

    SKF 96365, TRP channel blocker

  • 製品の詳細

    Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.

  • 生理活性の詳細

    Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.

  • 精製度

    > 99%

  • CAS 番号

    130495-35-1

  • 構造式

    Chemical Structure

製品の特性

画像

  • Functional Studies - SKF 96365, TRP channel blocker (ab120280)
    Functional Studies - SKF 96365, TRP channel blocker (ab120280)Sansone et al PLoS One. 2014; 9(1): e87721. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    TRP channel blockers affect most of the L-arginine-induced responses.

    L-arginine-induced Ca2+ responses of two ORNs of another individual slice of the lateral MOE (cyan and red trace). Incubation with SKF-96365 (80 µM; 10 min; lilac-shaded panel) led to a strong reduction of the Ca2+ transient in only one of the two ORNs (red trace). The response of the affected ORN recovered after 10 min of washout (right-hand traces). ORNs unaffected and affected by SKF-96365, expressed as percentage of total ORNs tested (histogram; 25 cells, 4 slices).

    (From Figure 5C of Sansone et al).

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献

ab120280 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab120280 は 12 報の論文で使用されています。

  • Chen J  et al. Roles and mechanisms of TRPC3 and the PLC?/PKC/CPI-17 signaling pathway in regulating parturition. Mol Med Rep 17:898-910 (2018). PubMed: 29115500
  • Lin EC  et al. Differential Contribution of Ca(2+)-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex. Front Cell Neurosci 11:182 (2017). PubMed: 28713246
  • Gazda K  et al. Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum. Sci Rep 7:14512 (2017). PubMed: 29109429
  • Zhu M  et al. Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer. Cell Death Dis 8:e2938 (2017). PubMed: 28726786
  • Abdoul-Azize S  et al. Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation. Oncotarget 8:27339-27352 (2017). PubMed: 28423696
View all Publications for this product

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Question

Dear ladies and gentlemen,



I have a technical question concerning the product SKF 96365 (product code: ab120280; former product code: Asc-280). Does this chemical consist of both stereoisomer or only one of them?



With best regards,

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Answer

Thanks for your email.



I can confirm that this is a racemic mixture of both stereoisomers.



If you need any further assistance in the future, please do not hesitate to contact me.

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