製品の概要

  • 製品名

    SKF 96365, TRP channel blocker
  • 製品の詳細

    Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
  • 生理活性の詳細

    Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
  • 精製度

    > 99%
  • CAS 番号

    130495-35-1
  • 構造式

    Chemical Structure

製品の特性

画像

  • TRP channel blockers affect most of the L-arginine-induced responses.

    L-arginine-induced Ca2+ responses of two ORNs of another individual slice of the lateral MOE (cyan and red trace). Incubation with SKF-96365 (80 µM; 10 min; lilac-shaded panel) led to a strong reduction of the Ca2+ transient in only one of the two ORNs (red trace). The response of the affected ORN recovered after 10 min of washout (right-hand traces). ORNs unaffected and affected by SKF-96365, expressed as percentage of total ORNs tested (histogram; 25 cells, 4 slices).

    (From Figure 5C of Sansone et al).

参考文献

This product has been referenced in:

  • Juvin V  et al. Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol 72:1258-68 (2007). Read more (PubMed: 17673572) »
  • Baba A  et al. Activity-evoked capacitative Ca2+ entry: implications in synaptic plasticity. J Neurosci 23:7737-41 (2003). Read more (PubMed: 12944501) »
  • Jan CR  et al. Multiple effects of 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF 96365) on Ca2+ signaling in MDCK cells: depletion of thapsigargin-sensitive Ca2+ store followed by capacitative Ca2+ entry, activation of a direct Ca2+ entry, and inhibition of thapsigargin-induced capacitative Ca2+ entry. Naunyn Schmiedebergs Arch Pharmacol 359:92-101 (1999). Read more (PubMed: 10048593) »
See all 8 Publications for this product

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