SKF 96365, TRP channel blocker (ab120280)
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- 文献 (8)
製品の概要
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製品名SKF 96365, TRP channel blocker
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製品の詳細Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
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生理活性の詳細Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
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精製度> 99%
製品の特性
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体系名1-[2-[3-(4-Methoxyphenyl)propoxy]-2-(4-methoxyphenyl)ethyl]-1H-imidazole hydrochloride
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分子量402.92
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構造式
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分子式C22H26N2O3.HCl
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CAS 番号130495-35-1
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PubChem 登録番号104955
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保存方法Store at Room Temperature. The product can be stored for up to 12 months.
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溶解性Soluble in water to 100 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記Cl.COc1ccc(cc1)C(OCCCc2ccc(OC)cc2)Cn3ccnc3
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由来
Synthetic
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研究分野
参考文献
This product has been referenced in:
- Juvin V et al. Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol 72:1258-68 (2007). Read more (PubMed: 17673572) »
- Baba A et al. Activity-evoked capacitative Ca2+ entry: implications in synaptic plasticity. J Neurosci 23:7737-41 (2003). Read more (PubMed: 12944501) »
- Jan CR et al. Multiple effects of 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF 96365) on Ca2+ signaling in MDCK cells: depletion of thapsigargin-sensitive Ca2+ store followed by capacitative Ca2+ entry, activation of a direct Ca2+ entry, and inhibition of thapsigargin-induced capacitative Ca2+ entry. Naunyn Schmiedebergs Arch Pharmacol 359:92-101 (1999). Read more (PubMed: 10048593) »