Anti-SEC63 抗体 (ab68550)
Key features and details
- Mouse polyclonal to SEC63
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SEC63 antibody
SEC63 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to SEC63 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein within Human SEC63. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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ポジティブ・コントロール
- Human pancreas lysate, SEC63 transfected 293T cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.40
Constituent: PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab68550の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Detects a band of approximately 88 kDa (predicted molecular weight: 88 kDa).
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特記事項 |
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WB
1/500 - 1/1000. Detects a band of approximately 88 kDa (predicted molecular weight: 88 kDa). |
ターゲット情報
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関連性
SEC63 and SEC62 proteins are found to be associated with the ribosome-free SEC61 complex, which is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Mutations in SEC63 cause autosomal dominant polycystic liver disease. -
細胞内局在
Endoplasmic reticulum membrane; Multi pass membrane protein. -
参照データベース
- Entrez Gene: 11231 Human
- Omim: 608648 Human
- SwissProt: Q9UGP8 Human
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別名
- ERdj2 antibody
- PRO2507 antibody
- SEC 63 antibody
see all
画像
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Anti-SEC63 antibody (ab68550) at 1/500 dilution + Human pancreas lysate at 50 µg
Secondary
Goat Anti-Mouse IgG (H&L) at 1/2500 dilution
Predicted band size: 88 kDa
Observed band size: 88 kDa -
All lanes : Anti-SEC63 antibody (ab68550) at 1/500 dilution
Lane 1 : SEC63 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L) at 1/2500 dilution
Predicted band size: 88 kDa
Observed band size: 88 kDa
データシートおよび資料
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Datasheet download
参考文献 (1)
ab68550 は 1 報の論文で使用されています。
- Singh S et al. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC. Biochemistry 59:2299-2311 (2020). PubMed: 32462874