製品の概要

  • 製品名

    SCH79797 dihydrochloride, PAR1 antagonist
  • 製品の詳細

    Potent and selective PAR1 antagonist
  • 生理活性の詳細

    Potent and selective non-peptide Proteinase-Activated Receptor-1 (PAR1) antagonist (IC50 = 70 nM). Protects against ischemic injury. Additionally induces apoptosis and inhibits cell proliferation.
  • 精製度

    > 98%
  • CAS 番号

    1216720-69-2
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • El Eter E & Aldrees A Inhibition of Pro-inflammatory Cytokines by SCH79797, a Selective PAR1 Antagonist, Protects Rat Kidney Against Ischemia Reperfusion Injury. Shock : (2012). Read more (PubMed: 22395241) »
  • Fujimoto D  et al. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer 10:443 (2010). Read more (PubMed: 20723226) »
  • Strande JL  et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Basic Res Cardiol 102:350-8 (2007). Read more (PubMed: 17468933) »
See 1 Publication for this product

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