Anti-Scavenging Receptor SR-BI 抗体 (ab106572)
Key features and details
- Rabbit polyclonal to Scavenging Receptor SR-BI
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Scavenging Receptor SR-BI antibody
Scavenging Receptor SR-BI 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Scavenging Receptor SR-BI -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
A 15 amino acid peptide near the amino terminus of Human Scavenging Receptor SR-BI.
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ポジティブ･コントロール
- WB: Human spleen tissue lysate IHC-P: Human spleen tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106572の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
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| IHC-P |
Use a concentration of 2.5 µg/ml.
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| 特記事項 |
|---|
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ICC/IF
Use a concentration of 20 µg/ml. |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa. |
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IHC-P
Use a concentration of 2.5 µg/ml. |
ターゲット情報
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機能
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. -
組織特異性
Widely expressed. -
配列類似性
Belongs to the CD36 family. -
翻訳後修飾
N-glycosylated. -
細胞内局在
Cell membrane. Membrane > caveola. Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. - Information by UniProt
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参照データベース
- Entrez Gene: 949 Human
- Omim: 601040 Human
- SwissProt: Q8WTV0 Human
- Unigene: 520348 Human
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別名
- CD36 and LIMPII analogous 1 antibody
- CD36 antibody
- CD36 Antigen like 1 antibody
see all
画像
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Western blot - Anti-Scavenging Receptor SR-BI antibody (ab106572)Lane 1 : Anti-Scavenging Receptor SR-BI antibody (ab106572) at 1 µg/ml
Lane 2 : Anti-Scavenging Receptor SR-BI antibody (ab106572) at 2 µg/ml
All lanes : Human spleen tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 61 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Scavenging Receptor SR-BI antibody (ab106572)Immunohistochemical analysis of Scavenging Receptor SR-BI in paraffin embedded Human spleen tissue sections, using ab106572 at 2.5 µg/ml. -
Immunocytochemistry/ Immunofluorescence - Anti-Scavenging Receptor SR-BI antibody (ab106572)Immunofluorescence of SCARB1 in Human Spleen cells using ab106572 at 20 ug/ml.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (7)
ab106572 は 7 報の論文で使用されています。
- Ursino GM et al. ABCA12 regulates insulin secretion from ß-cells. EMBO Rep 21:e48692 (2020). PubMed: 32072744
- Liu J et al. ZAP70 deficiency promotes reverse cholesterol transport through MAPK/ERK pathway in Jurkat cell. Mol Immunol 107:21-28 (2019). PubMed: 30639475
- Meng Z et al. Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells. Nutr Metab (Lond) 16:25 (2019). PubMed: 31049071
- Hu J et al. Silencing ZAP70 prevents HSP65-induced reverse cholesterol transport and NF-?B activation in T cells. Biomed Pharmacother 102:271-277 (2018). PubMed: 29567540
- Luo T et al. Lck Inhibits Heat Shock Protein 65-Mediated Reverse Cholesterol Transport in T Cells. J Immunol 197:3861-3870 (2016). PubMed: 27742830
- Sa-Ngiamsuntorn K et al. A robust model of natural hepatitis C infection using hepatocyte-like cells derived from human induced pluripotent stem cells as a long-term host. Virol J 13:59 (2016). PubMed: 27044429
- Yu R et al. Baicalin promotes cholesterol efflux by regulating the expression of SR-BI in macrophages. Exp Ther Med 12:4113-4120 (2016). PubMed: 28105139
