製品の概要

  • 製品名

    SB 399885 hydrochloride, 5-HT6 antagonist
  • 製品の詳細

    Potent, selective 5-HT6 antagonist
  • 生理活性の詳細

    Potent, selective competitive 5-HT6 antagonist (pKi values are 8.81 and 9.02 for rat and human native receptors, respectively). Orally active, cognitive enhancer in vivo. Displays >200-fold selectivity over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4, 5-HT7, α1B, D2, D3, D4 receptors, ion channels and a range of enzymes.
  • 精製度

    > 99%
  • CAS 番号

    402713-80-8
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Wesolowska A & Nikiforuk A Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52:1274-83 (2007). Read more (PubMed: 17320917) »
  • Hirst WD  et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol 553:109-19 (2006). Read more (PubMed: 17069795) »
  • Perez-García G & Meneses A Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol Biochem Behav 81:673-82 (2005). Read more (PubMed: 15964617) »

レビューと Q&A

Answer

Thank you for bringing this to our attention. The following link will bring you to an FAQ page that addresses your concerns. It is a good resource for answering questions about our biochemicals in general.

https://www.abcam.com/index.html?pageconfig=resource&rid=14735

Under the categories "Product appearance" and Product technical information" you will see:

Should different batches look the same?

It is not unusual for different batches of the same product to vary slightly in appearance and colour. However, this will not affect purity or quality as described on the batch specific Certificate of authenticity and will not affect product performance

Molecular weights and formula

The molecular weight and formula published on our website represent the molecular weight and formula of the product as depicted in the chemical structure displayed on our website. However, molecular weights (and formulae) can vary slightly from batch to batch - due to water composition, or due to a change of salt. These changes will be indicated on the Certificate of authenticity that accompanies your product. The changes should not affect the biological activity of your product, but it is important that you take them into account when making up solutions. You should therefore always use the batch molecular weight as stated on the Certificate of authenticity or the vial label.

I hope this is reassuring! If you have any other questions, please do not hesitate to contact us.

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