SAHA (Vorinostat), HDAC inhibitor (ab144480)
Key features and details
- Potent non-selective HDAC inhibitor
- CAS Number: 149647-78-9
- Purity: > 98%
- Soluble in ethanol to 50 mM (with warming) and in DMSO to 100mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SAHA (Vorinostat), HDAC inhibitor -
製品の詳細
Potent non-selective HDAC inhibitor -
別名
- Vorinostat
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生理活性の詳細
Potent non-selective HDAC inhibitor (IC50 values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC50 = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.
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精製度
> 98% -
CAS 番号
149647-78-9 -
構造式
製品の特性
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体系名
N1-Hydroxy-N8-phenyloctanediamide -
分子量
264.32 -
分子式
C14H20N2O3 -
PubChem 登録番号
5311 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 50 mM (with warming) and in DMSO to 100mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab144480 は 1 報の論文で使用されています。
- Sun RC et al. Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers. Cell Metab 30:903-916.e7 (2019). PubMed: 31523006