Anti-S100 抗体 [4C4.9] (ab4066)
Key features and details
- Mouse monoclonal [4C4.9] to S100
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-S100 antibody [4C4.9]
S100 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [4C4.9] to S100 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Full length protein. Purified bovine brain S-100 protein
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ポジティブ・コントロール
- IHC-P: Human Melanoma and skin tissue.
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特記事項
This product was changed from ascites to tissue culture supernatant on 29/01/2021. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.3
Preservative: 0.05% Sodium azide
Constituent: Tissue culture supernatant -
Concentration information loading...
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精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
4C4.9 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab4066の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (4) |
1/10 - 1/50. Antigen retrieval is not essential but may optimise staining.
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特記事項 |
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IHC-P
1/10 - 1/50. Antigen retrieval is not essential but may optimise staining. |
ターゲット情報
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機能
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. -
組織特異性
Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. -
配列類似性
Belongs to the S-100 family.
Contains 2 EF-hand domains. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 6271 Human
- Omim: 176940 Human
- SwissProt: P23297 Human
- Unigene: 515715 Human
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別名
- Bpb antibody
- NEF antibody
- Protein S100-A1 antibody
see all
画像
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Immunohistochemistry of Formalin fixed paraffin embedded human melanoma tissue sections labeling S100 with ab4066 at 1/100. (x10 magnification).
This image was generated using the ascites version of the product.
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Immunohistochemistry of Formalin fixed paraffin embedded human melanoma tissue sections labeling S100 with ab4066 at 1/100. (x10 magnification).
This image was generated using the ascites version of the product.
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Immunohistochemistry of Formalin fixed paraffin embedded human skin labeling S100 with ab4066.
This image was generated using the ascites version of the product.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (76)
ab4066 は 76 報の論文で使用されています。
- Sadeghmousavi S et al. The role of spinal cord tractography in detecting lesions following selective bladder afferent and efferent fibers injury: A novel method for induction of neurogenic lower urinary tract dysfunction in rabbit. Neurourol Urodyn 41:1539-1552 (2022). PubMed: 35842827
- Cruz E et al. Differential role of neuronal glucose and PFKFB3 in memory formation during development. Glia 70:2207-2231 (2022). PubMed: 35916383
- Qu H et al. Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease. Diabetes 70:1372-1387 (2021). PubMed: 33741719
- Hernández-Díaz N et al. Parallel evolution of placental calcium transfer in the lizard Mabuya and eutherian mammals. J Exp Biol 224:N/A (2021). PubMed: 33568441
- Wang Y et al. Betacellulin regulates peripheral nerve regeneration by affecting Schwann cell migration and axon elongation. Mol Med 27:27 (2021). PubMed: 33794764