(R,S)-CHPG, mGlu5 agonist (ab120039)
Key features and details
- Selective mGlu5 agonist
- CAS Number: 170846-74-9
- Soluble in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(R,S)-CHPG, mGlu5 agonist -
製品の詳細
Selective mGlu5 agonist -
生理活性の詳細
Selective mGlu5 receptor agonist. Water soluble form available - see (ab120221)
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CAS 番号
170846-74-9 -
構造式
製品の特性
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体系名
(R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid -
分子量
201.61 -
分子式
C8H8NO3Cl -
PubChem 登録番号
3645780 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 1 eq. NaOH to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
NC(c1cc(O)ccc1Cl)C(=O)O -
由来
Synthetic
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研究分野
関連製品
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アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120039の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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2D chemical structure image of ab120039, (R,S)-CHPG, mGlu5 agonist
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SK-N-SH cells were incubated at 37°C for 30 minutes with vehicle control (0 µM) and different concentrations of (R,S)-CHPG (ab120039). Increased expression of CREB (phospho S133) in SK-N-SH cells correlates with an increase in (R,S)-CHPG concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab32096 at 1/500 dilution and ab32515 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120039 は 3 報の論文で使用されています。
- Fontanez-Nuin DE et al. Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons. Cereb Cortex 21:727-35 (2011). PubMed: 20705895
- Le Duigou C & Kullmann DM Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons. J Neurosci 31:5777-81 (2011). PubMed: 21490219
- Besheer J et al. Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. J Neurosci 29:9582-91 (2009). PubMed: 19641121