RS 102895 hydrochloride, CCR2 receptor antagonist (ab120812)
Key features and details
- Selective CCR2 receptor antagonist
- CAS Number: 1173022-16-6
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
RS 102895 hydrochloride, CCR2 receptor antagonist -
製品の詳細
Selective CCR2 receptor antagonist -
生理活性の詳細
Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
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精製度
> 99% -
CAS 番号
1173022-16-6 -
構造式
製品の特性
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体系名
1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride -
分子量
426.86 -
分子式
C21H21F3N2O2.HCl -
PubChem 登録番号
16759153 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120812 は 4 報の論文で使用されています。
- Wang JB et al. CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages. Cancer Gene Ther N/A:N/A (2022). PubMed: 35999359
- Zhan X et al. Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration. BMC Dev Biol 20:20 (2020). PubMed: 33023470
- Han S et al. High CCL7 expression is associated with migration, invasion and bone metastasis of non-small cell lung cancer cells. Am J Transl Res 11:442-452 (2019). PubMed: 30788000
- Maolake A et al. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 axis. Oncotarget 8:9739-9751 (2017). PubMed: 28039457