製品の概要

  • 製品名

    Rotigotine hydrochloride, Dopamine receptor agonist
  • 製品の詳細

    Dopamine receptor agonist
  • 別名

    • N 0923
  • 生理活性の詳細

    Dopamine receptor agonist. High affinity for D1, D2 and D3 receptors (Ki values are 83, 13 and 0.71 nM, respectively). Shows significant affinity at α2B and 5-HT1A receptors (Ki values are 27 and 30 nM, respectively). Exhibits anti-Parkinsonian and antidepressant activity.
  • 精製度

    > 99%
  • CAS 番号

    125572-93-2
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Scheller D  et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol 379:73-86 (2009). Read more (PubMed: 18704368) »
  • Scheller D  et al. Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson's disease. Neurosci Lett 432:30-4 (2008). Read more (PubMed: 18162314) »
  • Bertaina-Anglade V  et al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol 548:106-14 (2006). Read more (PubMed: 16959244) »

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