Anti-ROS1 (phospho Y2114) 抗体 (ab191522)
Key features and details
- Rabbit polyclonal to ROS1 (phospho Y2114)
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-ROS1 (phospho Y2114) antibody
ROS1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ROS1 (phospho Y2114) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Synthetic peptide within Human ROS1 (phospho Y2114). The exact sequence is proprietary. Synthetic phosphopeptide derived from human ROS1 around the phosphorylation site of Tyrosine 2114.
Database link: P08922 -
ポジティブ・コントロール
- SKOVCAR, Raw264.7 and PC12 whole cell lysates
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.20
Preservative: 0.05% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab191522 affinity purified from Rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is > 95% (by SDS-PAGE). -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab191522の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500. Predicted molecular weight: 264 kDa.
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特記事項 |
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WB
1/500. Predicted molecular weight: 264 kDa. |
ターゲット情報
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機能
This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity. -
組織特異性
Expressed in brain. Expression is increased in primary gliomas. -
関連疾患
Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 9 fibronectin type-III domains.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6098 Human
- Entrez Gene: 19886 Mouse
- Entrez Gene: 25346 Rat
- Omim: 165020 Human
- SwissProt: P08922 Human
- SwissProt: Q78DX7 Mouse
- SwissProt: Q63132 Rat
- Unigene: 1041 Human
see all -
別名
- c ros 1 antibody
- c ros antibody
- c ros oncogene 1 receptor tyrosine kinase antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (2)
ab191522 は 2 報の論文で使用されています。
- Wang L et al. P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation. IUBMB Life 71:45-56 (2019). PubMed: 30321484
- Zhao X & Wang X Candesartan targeting of angiotensin II type 1 receptor demonstrates benefits for hypertension in pregnancy via the NF-?B signaling pathway. Mol Med Rep 18:705-714 (2018). PubMed: 29845261