Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor (ab141491)
Key features and details
- Selective cyclin-dependent kinase (Cdk1) inhibitor
- CAS Number: 872573-93-8
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
Ro 3306, cyclin-dependent kinase (Cdk1) inhibitor -
製品の詳細
Selective cyclin-dependent kinase (Cdk1) inhibitor -
生理活性の詳細
Selective cyclin-dependent kinase (Cdk1) inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A, respectively). Enhances downstream p53 signaling. Induces G2/M-phase cell cycle arrest and apoptosis.
-
精製度
> 99% -
CAS 番号
872573-93-8 -
構造式
製品の特性
-
体系名
(5Z)-5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino)-4(5H)-thiazolone -
分子量
351.44 -
分子式
C18H13N3OS2 -
PubChem 登録番号
11631681 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
C1=CC2=C(C=CC(=C2)/C=C\3/C(=O)N=C(S3)NCC4=CC=CS4)N=C1 -
由来
Synthetic
-
研究分野
- Biochemicals
- Research Area
- Alzheimer's Disease
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Pain & inflammation
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab141491 は 5 報の論文で使用されています。
- Zhang Y et al. Caudatin Inhibits the Proliferation, Invasion, and Glycolysis of Osteosarcoma Cells via the Wnt/β- Catenin Pathway. Evid Based Complement Alternat Med 2022:4026688 (2022). PubMed: 36588592
- Huang CR et al. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Nat Commun 12:90 (2021). PubMed: 33397943
- Matsubara S et al. Fractionation of Ovarian Follicles and in vitro Oocyte Maturation and Ovulation Assay of Ciona intestinalis Type A. Bio Protoc 10:e3577 (2020). PubMed: 33659547
- Mukherjee A et al. Nuclear plasticity increases susceptibility to damage during confined migration. PLoS Comput Biol 16:e1008300 (2020). PubMed: 33035221
- Matsubara S et al. The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates. Elife 8:N/A (2019). PubMed: 31573508