製品の概要

  • 製品名

    Ro 25-6981 maleate salt, NR2B antagonist
  • 製品の詳細

    NR2B antagonist
  • 別名

    • Ro25-6981 maleate salt
  • 生理活性の詳細

    Potent, highly selective, activity-dependent blocker of NMDA receptors that contain the NR2B subunit (IC50 values are 0.009 and 52 μM at NR1C/NR2B and NR1C/NR2A, respectively). Displays no significant activity at kainate/AMPA receptors, Na+ and Ca2+ channels at concentrations showing maximal protection in neurotoxicity tests. Neuroprotective actions in vivo and in vitro.

    Also available in simple stock solutions (ab146695) - add 1 ml of water to get an exact, ready-to-use concentration.

  • 精製度

    > 98%
  • CAS 番号

    169274-78-6
  • 構造式

    Chemical Structure

製品の特性

画像

  • Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of Ro 25-6981 (0.2, 2.0, or 10 μM; ab120290) in slices from naive adult male C57BL/6J mice.

参考文献

This product has been referenced in:

  • Chazot PL The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. Curr Med Chem 11:389-96 (2004). Read more (PubMed: 14965239) »
  • Lynch DR  et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol 416:185-95 (2001). Read more (PubMed: 11290368) »
  • Fischer G  et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 283:1285-92 (1997). Read more (PubMed: 9400004) »
See all 8 Publications for this product

レビューと Q&A

1-2 of 2 Abreviews or Q&A

Answer


As we do not carry out any biological studies of our products in vivo, we therefore recommend that you review the published literature for dosage guidelines.
To assist you in your product selection, we provide a brief summary of the biological properties of our products, together with some suggested reading (references) that you may find useful. Please note, that whilst this information is given as accurately as possible on our website, it may not always reflect the latest findings and is not exhaustive. It is intended as a guide only and we therefore recommend that you carry out your own search of the scientific literature for full details of the product's biological activity.
I found in the following artice, http://europepmc.org/articles/PMC2939157, that the elimination T1/2 for Ro 25-6981 is 5.1 hours for mice.

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Answer

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number . To check the status of the order please contact our Customer Service team and reference this number. Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know. I wish you the best of luck with your research.

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