Risperidone, 5-HT2A / D2 antagonist (ab120393)
Key features and details
- Atypical antipsychotic. 5-HT2A / D2 antagonist.
- CAS Number: 106266-06-2
- Soluble in DMSO to 10 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Risperidone, 5-HT2A / D2 antagonist -
製品の詳細
Atypical antipsychotic. 5-HT2A / D2 antagonist. -
生理活性の詳細
Atypical antipsychotic agent. Potent 5-HT2A antagonist (Ki = 0.4 nM). Also displays high affinity at D2 receptors (Ki = 3.13 nM).
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CAS 番号
106266-06-2 -
構造式
製品の特性
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体系名
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one -
分子量
410.48 -
分子式
C23H27FN4O2 -
PubChem 登録番号
5073 -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM and in ethanol to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC=5N=C1CCCCN1C(=O)C=5CCN2CCC(CC2)c4noc3cc(F)ccc34 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120393 は 3 報の論文で使用されています。
- Malekizadeh Y et al. Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects. Alzheimers Dement (N Y) 6:e12078 (2020). PubMed: 32864416
- Blessing WW et al. Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience. Psychopharmacology (Berl) 234:3259-3269 (2017). PubMed: 28812124
- Fijal K et al. Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats. Psychopharmacology (Berl) 231:269-81 (2014). Rat . PubMed: 23954911