製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to RGS4
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 153-183 of Human RGS4.

  • ポジティブ・コントロール
    • MDA-MB231 cell line lysate; Mouse brain tissue lysate; 293 cell lysate transiently transfected with the RGS4 gene.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab135725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 23 kDa.

ターゲット情報

  • 機能
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • 関連疾患
    Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • 配列類似性
    Contains 1 RGS domain.
  • 翻訳後修飾
    Palmitoylated on Cys-2 and/or Cys-12.
    Phosphorylated by cyclic GMP-dependent protein kinase.
  • Information by UniProt
  • 参照データベース
  • 別名
    • MGC2124 antibody
    • MGC60244 antibody
    • Regulator of G protein signalling 4 antibody
    • Regulator of G-protein signaling 4 antibody
    • RGP 4 antibody
    • RGP4 antibody
    • RGS 4 antibody
    • RGS4 antibody
    • RGS4_HUMAN antibody
    • Schizophrenia disorder 9 antibody
    • SCZD 9 antibody
    • SCZD9 antibody
    see all

画像

  • Anti-RGS4 antibody (ab135725) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size: 23 kDa

  • Anti-RGS4 antibody (ab135725) at 1/100 dilution + Mouse brain tissue lysate at 35 µg

    Predicted band size: 23 kDa

  • All lanes : Anti-RGS4 antibody (ab135725) at 1/100 dilution

    Lane 1 : 293 cell lysate, non-transfected
    Lane 2 : 293 cell lysate, transiently transfected with the RGS4 gene

    Lysates/proteins at 2 µg per lane.

    Predicted band size: 23 kDa

プロトコール

参考文献

ab135725 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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