製品の概要

  • 製品名
    RG 108, non-nucleoside DNA methyltransferase inhibitor (DNMT)
  • 製品の詳細
    Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT)
  • 生理活性の詳細
    Novel, non-nucleoside DNA methyltransferase (DNMT) inhibitor, capable of interacting with the DNMT1 active site (IC50 = 115 nM). Inhibits DNA methylation in human cancer cell lines. Reactivates several epigenetically silenced tumour suppressor genes in vitro. Capable of enhancing the efficiency of induced pluripotent stem cell (iPS) generation.
  • 精製度
    > 99%
  • CAS 番号
    48208-26-0
  • 構造式
    Chemical Structure

製品の特性

参考文献

This product has been referenced in:
  • Savickiene J  et al. Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells. Cell Mol Biol Lett 17:501-25 (2012). Read more (PubMed: 22820861) »
  • Savickiene J  et al. DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling. Cell Biol Int 36:1067-78 (2012). Read more (PubMed: 22845560) »
  • Stresemann C  et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 66:2794-800 (2006). Read more (PubMed: 16510601) »
  • Brueckner B  et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 65:6305-11 (2005). Read more (PubMed: 16024632) »
See 1 Publication for this product

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