製品の概要

  • 製品名

    Resiniferatoxin
  • 製品の詳細

    Ultrapotent TRPV1 agonist
  • 生理活性の詳細

    Highly potent capsaicin analogue that acts as an agonist at TRPV1 channels (vanilloid receptor) (Ki = 43 pM).
  • 精製度

    > 98%
  • CAS 番号

    57444-62-9
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Willis WD The role of TRPV1 receptors in pain evoked by noxious thermal and chemical stimuli. Exp Brain Res 196:5-11 (2009). Read more (PubMed: 19294370) »
  • Szallasi A & Blumberg PM Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci 47:1399-408 (1990). Read more (PubMed: 2174484) »
  • Szolcsanyi J  et al. Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J Pharmacol Exp Ther 255:923-8 (1990). Read more (PubMed: 2243359) »
See 1 Publication for this product

レビューと Q&A

1-2 of 2 Abreviews or Q&A

Answer

I unfortunately will not be able to answer your question, as we do not do this kind of testing. You have more information, from your literature search, than we do regarding dosing. Comparing dosages experimentally in a diagnostic "pre"- experiment may be useful.

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Answer

Resiniferatoxin (RTX) is insoluble in water, so you will need to prepare a stock solution by reconstituting it in DMSO. For a 100mM solution, my calculations show that adding 16ul DMSO to the 1mg of RTX will yield a 100mM solution. However, you may find that adding twice that volume, 32ul for a 50mM solution, or more, will make it easier to dissolve the lyophilized RTX.

I am assuming you can further dilute the stock solution in the the 10% Tween-80, 10% ethanol in normal saline without the RTX coming out of solution, but we have not tried this.

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