Anti-Red Blood Cells 抗体 [34-3C] (ab106101)
Key features and details
- Mouse monoclonal [34-3C] to Red Blood Cells
- Suitable for: Flow Cyt, Functional Studies
- Reacts with: Mouse
- Isotype: IgG2a
製品の概要
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製品名
Anti-Red Blood Cells antibody [34-3C]
Red Blood Cells 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [34-3C] to Red Blood Cells -
由来種
Mouse -
特異性
Recognizes an exposed surface determinant of intact Red Blood Cells. ab106101 only recognises antigenic determinants expressed on Mouse RBC and not on other species of RBC. -
アプリケーション
適用あり: Flow Cyt, Functional Studiesmore details -
種交差性
交差種: Mouse
非交差種: Rat, Sheep, Rabbit, Chicken, Human -
免疫原
Tissue, cells or virus corresponding to Mouse Red Blood Cells.
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ポジティブ・コントロール
- Mouse erythrocytes
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特記事項
This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
0.2 µm filtered solution -
一次抗体 備考
This antibody efficiently binds to Fc receptors on macrophages inducing anemia in vivo due to a rapid Fc receptor (FcyR)-mediated erythrophagocytosis of opsonised RBC in spleen and livers. The capacity of the antibody to interact with FcyR is responsible for its haemolytic activity. -
ポリ/モノ
モノクローナル -
クローン名
34-3C -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106101の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
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Functional Studies |
Use at an assay dependent concentration.
|
特記事項 |
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Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Functional Studies
Use at an assay dependent concentration. |
ターゲット情報
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関連性
Red blood cells are the most common type of blood cell and are the vertebrate body's principal means of delivering oxygen from the lungs or gills to body tissues via the blood. -
別名
- Erythrocytes antibody
- RBCs antibody
データシートおよび資料
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Datasheet download
参考文献 (4)
ab106101 は 4 報の論文で使用されています。
- Akter J et al. Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathog 15:e1007599 (2019). PubMed: 30811498
- Baudino L et al. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180:1948-53 (2008). PubMed: 18209093
- Azeredo da Silveira S et al. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med 195:665-72 (2002). PubMed: 11901193
- Fossati-Jimack L et al. High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. J Exp Med 190:1689-96 (1999). PubMed: 10587359