Key features and details
- Expression system: HEK 293 cells
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
製品名Recombinant Rat Prorenin protein
Prorenin タンパク質・ペプチド 製品一覧
精製度> 95 % SDS-PAGE.
Purified by chelated metal affinity chromatography
発現系HEK 293 cells
タンパク質長Full length protein
Our Abpromise guarantee covers the use of ab92748 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituent: 0.605% Tris
- Angiotensin forming enzyme
機能Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
関連疾患Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
配列類似性Belongs to the peptidase A1 family.
細胞内局在Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab92748 は 1 報の論文で使用されています。
- Urushihara M et al. (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/ß-catenin pathways in glomerulonephritis. Am J Physiol Renal Physiol 319:F571-F578 (2020). PubMed: 32830537