Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE
- High batch-to-batch consistency
- Optimal bioactivity
- Guaranteed identical to human native proteins
- >95% purity
- Ultra-low endotoxin levels: <0.005 Eu/µg
- Carrier and tag free
製品名Recombinant rat IL-6 protein
IL-6 タンパク質・ペプチド 製品一覧
精製度> 95 % SDS-PAGE.
Sterile filtered Greater than 95% pure by HPLC analyses. Endotoxin level is less than 0.1 ng per g (1EU/g).
タンパク質長Full length protein
配列Recombinant Rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues: MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITY VLREIF EMRKELCNGN SDCMNSDDALSENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQSNTETLV HIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LK ALEEFLKVTMRSTRQT
Our Abpromise guarantee covers the use of ab9771 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 1 x 108 units/mg.
Concentration information loading...
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
再構成We recommend a quick spin followed by reconstitution in 100ul water or buffer at pH 7.0 to a concentration of 0.1mg/ml.
- Interleukin BSF 2
- B cell differentiation factor
- B cell stimulatory factor 2
機能Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
関連疾患Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
配列類似性Belongs to the IL-6 superfamily.
翻訳後修飾N- and O-glycosylated.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.