製品の詳細

  • 製品名

    Recombinant Mouse Tyrosine Hydroxylase protein (His tag)
    Tyrosine Hydroxylase タンパク質・ペプチド 製品一覧
  • 精製度

    > 90 % SDS-PAGE.
    ab219278 was purified by using conventional chromatography techniques.
  • エンドトキシン・レベル

    < 1.000 Eu/µg
  • 発現系

    Baculovirus infected insect cells
  • アクセッション番号

  • タンパク質長

    Full length protein
  • Animal free

    No
  • 由来

    Recombinant
    • 生物種

      Mouse
    • 配列

      ADPMPTPSAS SPQPKGFRRA VSEQDTKQAE AVTSPRFIGR RQSLIEDARK EREAAAAAAA AAVASAEPGN PLEAVVFEER DGNAVLNLLF SLRGTKPSSL SRALKVFETF EAKIHHLETR PAQRPLAGSP HLEYFVRFEV PSGDLAALLS SVRRVSDDVR SAREDKVPWF PRKVSELDKC HHLVTKFDPD LDLDHPGFSD QAYRQRRKLI AEIAFQYKQG EPIPHVEYTK EEIATWKEVY ATLKGLYATH ACREHLEAFQ LLERYCGYRE DSIPQLEDVS HFLKERTGFQ LRPVAGLLSA RDFLASLAFR VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADRTFAQ FSQDIGLASL GASDEEIEKL STVYWFTVEF GLCKQNGELK AYGAGLLSSY GELLHSLSEE PEVRAFDPDT AAVQPYQDQT YQPVYFVSES FSDAKDKLRN YASRIQRPFS VKFDPYTLAI DVLDSPHTIR RSLEGVQDEL HTLTQALSAI SHHHHHH
    • 予測される分子量

      57 kDa including tags
    • 領域

      1 to 498
    • タグ

      His tag C-Terminus

特性

Our Abpromise guarantee covers the use of ab219278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態

    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 90% PBS, 10% Glycerol

関連情報

  • 別名

    • Dystonia 14
    • DYT14
    • DYT5b
    • EC 1.14.16.2
    • OTTHUMP00000011225
    • OTTHUMP00000011226
    • ple
    • Protein Pale
    • TH
    • The
    • TY3H_HUMAN
    • TYH
    • Tyrosine 3 hydroxylase
    • Tyrosine 3 monooxygenase
    • Tyrosine 3-hydroxylase
    • Tyrosine 3-monooxygenase
    • Tyrosine hydroxylase
    see all
  • 機能

    Plays an important role in the physiology of adrenergic neurons.
  • 組織特異性

    Mainly expressed in the brain and adrenal glands.
  • パスウェイ

    Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
  • 関連疾患

    Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
    Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
  • 配列類似性

    Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  • Information by UniProt

画像

  • 15% SDS-PAGE - Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278) at 3 μg.

参考文献

ab219278 has not yet been referenced specifically in any publications.

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