Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 2% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: SDS-PAGE, Functional Studies
製品名Recombinant mouse PDE6C protein (Active)
PDE6C タンパク質・ペプチド 製品一覧
生理活性Specific Activity ≥ 600 pmol/min/µg.Unit Definition: One unit is defined as the amount of enzyme that will convert 1 pmole of 3′, 5′-cGMP to 5′-GMP per min at 37°C.
精製度>= 2 % SDS-PAGE.
発現系Baculovirus infected Sf9 cells
タンパク質長Full length protein
領域2 to 861
タグGST tag N-Terminus
Our Abpromise guarantee covers the use of ab271683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.31% Glutathione, 0.05% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 20% Glycerol (glycerin, glycerine)
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 5''-cyclic phosphodiesterase subunit alpha''
- cGMP phosphodiesterase 6C
関連疾患Defects in PDE6C are the cause of cone dystrophy type 4 (COD4) [MIM:613093]. An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
配列類似性Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.