製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    HEK 293 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Mouse
    • 配列
      SGWLLEVPNGPWRSLTFYPAWLTVSEGANATFTCSLSNWSEDLMLNWNRL SPSNQTEKQAAFCNGLSQPVQDARFQIIQLPNRHDFHMNILDTRRNDSGI YLCGAISLHPKAKIEESPGAELVVTERILETSTRYPSPSPKPEGRFQ
    • 分子量
      17 kDa including tags
    • 領域
      21 to 167
    • タグ
      His tag C-Terminus
    • 配列の追加情報
      (NP_032824)

特性

Our Abpromise guarantee covers the use of ab180051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性

    Bioactivity was measured by binding ability in a functional ELISA. Immobilized Recombinant Mouse PD1 /PDCD1 Protein (ab180051) at 5 μg/ml (100 μl/well) can bind Recombinant Mouse PD-L1 /CD274 /B7-H1 protein with C-Fc Tag with a linear range of 0.2-2 μg/ml.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • エンドトキシン・レベル
    < 1.000 Eu/µg
  • 精製度
    >95% by SDS-PAGE .

  • 製品の状態
    Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).

    pH: 7.40
    Constituents: 95% PBS, 5% Trehalose

    Lyophilized from 0.22 µm filtered solution.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 再構成
    It is recommended to reconstitute the lyophilized protein in deionized water to a final concentration of 400 µg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing.

関連情報

  • 別名
    • CD279
    • CD279 antigen
    • hPD 1
    • hPD l
    • hPD-1
    • hSLE1
    • PD 1
    • PD-1
    • PD1
    • PDCD 1
    • PDCD1
    • PDCD1_HUMAN
    • Programmed cell death 1
    • Programmed cell death 1 protein
    • Programmed cell death protein 1
    • Protein PD 1
    • Protein PD-1
    • SLEB2
    • Systemic lupus erythematosus susceptibility 2
    see all
  • 機能
    Possible cell death inducer, in association with other factors.
  • 関連疾患
    Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 配列類似性
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 発生段階
    Induced at programmed cell death.
  • 細胞内局在
    Membrane.
  • Information by UniProt

画像

  • SDS-PAGE analysis of PD1 in reducing conditions. Gel stained overnight with Coomassie Blue. Protein migrates as 25 - 45 kDa due to different glycosylation.

参考文献

ab180051 has not yet been referenced specifically in any publications.

レビューと Q&A

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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