Recombinant Human sTRAIL Receptor 2 protein (ab643)

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製品の概要

製品の詳細

  • 由来

    Recombinant

  • 由来

    Escherichia coli
  • アミノ酸配列

    • 生物種

      Human

    • 配列

      MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES

    • 分子量

      15 kDa

特性

Our Abpromise guarantee covers the use of ab643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態

    Lyophilised

  • 備考

    Biological Activity : Determined by its ability to inhibit apoptosis induced by Human sTRAIL/Apo2L in LN-18 cells (human glioblastoma cells).

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

  • 再構成
    RECONSTITUTE IN WATER TO A CONCENTRATION OF 1 MG/ML

関連情報

  • 別名

    • Apoptosis inducing protein TRICK2A 2B
    • Apoptosis inducing protein TRICK2A/2B
    • Apoptosis inducing receptor TRAIL R2
    • CD262
    • CD262 antigen
    • Cytotoxic TRAIL receptor 2
    • Death domain containing receptor for TRAIL Apo 2L
    • Death receptor 5
    • DR5
    • Fas like protein
    • Killer
    • Killer DR5
    • KILLER/DR5
    • p53 regulated DNA damage inducible cell death receptor killer
    • p53 regulated DNA damage inducible cell death receptor(killer)
    • TNF receptor superfamily member 10b
    • TNF related apoptosis inducing ligand receptor 2
    • TNF-related apoptosis-inducing ligand receptor 2
    • TNFRSF10B
    • TR10B_HUMAN
    • Trail R2
    • TRAIL receptor 2
    • TRAIL-R2
    • TRAILR2
    • TRICK2
    • TRICK2A
    • TRICK2B
    • TRICKB
    • Tumor necrosis factor receptor like protein ZTNFR9
    • Tumor necrosis factor receptor superfamily member 10B
    • Tumor necrosis factor receptor superfamily, member 10b
    • ZTNFR9
    see all

  • 機能

    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

  • 組織特異性

    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

  • 関連疾患

    Squamous cell carcinoma of the head and neck

  • 配列類似性

    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.

  • 細胞内局在

    Membrane.
  • Information by UniProt

参考文献

ab643 has not yet been referenced specifically in any publications.

ab643 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

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