Recombinant Human sTRAIL Receptor 2 protein (ab643)

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製品の詳細

  • 製品名

    Recombinant Human sTRAIL Receptor 2 protein
    sTRAIL Receptor 2 タンパク質・ペプチド 製品一覧

  • 発現系

    Escherichia coli

  • タンパク質長

    Full length protein

  • Animal free

    No

  • 由来

    Recombinant

    • 生物種

      Human

    • 配列

      MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES

    • 予測される分子量

      15 kDa

特性

Our Abpromise guarantee covers the use of ab643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 製品の状態

    Lyophilized

  • 備考

    Biological Activity : Determined by its ability to inhibit apoptosis induced by Human sTRAIL/Apo2L in LN-18 cells (human glioblastoma cells).

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

  • 再構成
    RECONSTITUTE IN WATER TO A CONCENTRATION OF 1 MG/ML

関連情報

  • 別名

    • Apoptosis inducing protein TRICK2A 2B
    • Apoptosis inducing protein TRICK2A/2B
    • Apoptosis inducing receptor TRAIL R2
    • CD262
    • CD262 antigen
    • Cytotoxic TRAIL receptor 2
    • Death domain containing receptor for TRAIL Apo 2L
    • Death receptor 5
    • DR5
    • Fas like protein
    • Killer
    • Killer DR5
    • KILLER/DR5
    • p53 regulated DNA damage inducible cell death receptor killer
    • p53 regulated DNA damage inducible cell death receptor(killer)
    • TNF receptor superfamily member 10b
    • TNF related apoptosis inducing ligand receptor 2
    • TNF-related apoptosis-inducing ligand receptor 2
    • TNFRSF10B
    • TR10B_HUMAN
    • Trail R2
    • TRAIL receptor 2
    • TRAIL-R2
    • TRAILR2
    • TRICK2
    • TRICK2A
    • TRICK2B
    • TRICKB
    • Tumor necrosis factor receptor like protein ZTNFR9
    • Tumor necrosis factor receptor superfamily member 10B
    • Tumor necrosis factor receptor superfamily, member 10b
    • ZTNFR9
    see all

  • 機能

    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

  • 組織特異性

    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

  • 関連疾患

    Squamous cell carcinoma of the head and neck

  • 配列類似性

    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.

  • 細胞内局在

    Membrane.
  • Information by UniProt

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献

ab643 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab643 は論文での使用が確認できていません。

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