Key features and details
- Expression system: Baculovirus
- Purity: > 70% Densitometry
- Active: Yes
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, Functional Studies
製品名Recombinant human SIRT2 protein
SIRT2 タンパク質・ペプチド 製品一覧
Specific Activity: 8000 RLU/min/ng.
精製度> 70 % Densitometry.
The purity of SIRT2 was determined to be > 70% by densitometry. Affinity purified.
タンパク質長Full length protein
予測される分子量42 kDa including tags
領域2 to 352
タグHis tag N-Terminus
Our Abpromise guarantee covers the use of ab101132 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Preservative: 1.02% Imidazole
Constituents: 0.00174% PMSF, 0.82% Sodium phosphate, 0.00385% DTT, 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- NAD dependent deacetylase sirtuin 2
機能NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
組織特異性Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
配列類似性Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
発生段階Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
翻訳後修飾Phosphorylated at the G2/M transition of the cell cycle.
細胞内局在Cytoplasm > cytoskeleton. Colocalizes with microtubules.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.