Recombinant Human NLRP3 protein (Tagged) (ab271636)
Key features and details
- Expression system: HEK 293 cells
- Purity: > 75% SDS-PAGE
- Tags: DDDDK tag N-Terminus
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Human NLRP3 protein (Tagged)
NLRP3 タンパク質・ペプチド 製品一覧 -
精製度
> 75 % SDS-PAGE. -
発現系
HEK 293 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
KDYRKKYRKY VRSRFQCIED RNARLGESVS LNKRYTRLRL IKEHRSQQER EQELLAIGKT KTCESPVSPI KMELLFDPDD EHSEPVHTVV FQGAAGIGKT ILARKMMLDW ASGTLYQDRF DYLFYIHCRE VSLVTQRSLG DLIMSCCPDP NPPIHKIVRK PSRILFLMDG FDELQGAFDE HIGPLCTDWQ KAERGDILLS SLIRKKLLPE ASLLITTRPV ALEKLQHLLD HPRHVEILGF SEAKRKEYFF KYFSDEAQAR AAFSLIQENE VLFTMCFIPL VCWIVCTGLK QQMESGKSLA QTSKTTTAVY VFFLSSLLQP RGGSQEHGLC AHLWGLCSLA ADGIWNQKIL FEESDLRNHG LQKADVSAFL RMNLFQKEVD CEKFYSFIHM TFQEFFAAMY YLLEEEKEGR TNVPGSRLKL PSRDVTVLLE NYGKFEKGYL IFVVRFLFGL VNQERTSYLE KKLSCKISQQ IRLELLKWIE VKAKAKKLQI QPSQLELFYC LYEMQEEDFV QRAMDYFPKI EINLSTRMDH MVSSFCIENC HRVESLSLGF LHNMPKEEEE EEKEGRHLDM VQCVLPSSSH AACSHGLVNS HLTSSFCRGL FSVLSTSQSL TELDLSDNSL GDPGMRVLCE TLQHPGCNIR RLWLGRCGLS HECCFDISLV LSSNQKLVEL DLSDNALGDF GIRLLCVGLK HLLCNLKKLW LVSCCLTSAC CQDLASVLST SHSLTRLYVG ENALGDSGVA ILCEKAKNPQ CNLQKLGLVN SGLTSVCCSA LSSVLSTNQN LTHLYLRGNT LGDKGIKLLC EGLLHPDCKL QVLELDNCNL TSHCCWDLST LLTSSQSLRK LSLGNNDLGD LGVMMFCEVL KQQSCLLQNL GLSEMYFNYE TKSALETLQE EKPELTVVFE PSW -
予測される分子量
105 kDa -
領域
134 to 1036 -
タグ
DDDDK tag N-Terminus
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特性
Our Abpromise guarantee covers the use of ab271636 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol (glycerin, glycerine), 0.05% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
関連情報
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別名
- AGTAVPRL
- AII/AVP
- Angiotensin/vasopressin receptor AII/AVP like
see all -
機能
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. -
組織特異性
Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. -
関連疾患
Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1) [MIM:120100]; also known as familial cold urticaria. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.
Defects in NLRP3 are a cause of Muckle-Wells syndrome (MWS) [MIM:191900]; also known as urticaria-deafness-amyloidosis syndrome. MWS is a hereditary periodic fever syndrome characterized by fever, chronic recurrent urticaria, arthralgias, progressive sensorineural deafness, and reactive renal amyloidosis. The disease may be severe if generalized amyloidosis occurs.
Defects in NLRP3 are the cause of chronic infantile neurologic cutaneous and articular syndrome (CINCA) [MIM:607115]; also known as neonatal onset multisystem inflammatory disease (NOMID). CINCA is a rare congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms, chronic meningitis and joint manifestations with recurrent fever and inflammation. -
配列類似性
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
細胞内局在
Cytoplasm. - Information by UniProt
画像
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SDS-PAGE - Recombinant Human NLRP3 protein (Tagged) (ab271636)
SDS-PAGE analysis of ab271636.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
参考文献 (0)
ab271636 は論文での使用が確認できていません。
