Recombinant human MERTK protein (Active) (ab271471)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: Flow Cyt, SDS-PAGE
製品の詳細
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製品名
Recombinant human MERTK protein (Active)
MERTK タンパク質・ペプチド 製品一覧 -
生理活性
Specific activity ≥50 pmol/min/µg.
Assay was done in kinase buffer containing 1 mM DTT using Poly- (Glu4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min.
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精製度
>= 90 % SDS-PAGE. -
発現系
Baculovirus infected Sf9 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
EDVVIDRNLL ILGKILGEGE FGSVMEGNLK QEDGTSLKVA VKTMKLDNSS QREIEEFLSE AACMKDFSHP NVIRLLGVCI EMSSQGIPKP MVILPFMKYG DLHTYLLYSR LETGPKHIPL QTLLKFMVDI ALGMEYLSNR NFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI AIESLADRVY TSKSDVWAFG VTMWEIATRG MTPYPGVQNH EMYDYLLHGH RLKQPEDCLD ELYEIMYSCW RTDPLDRPTF SVLRLQLEKL LESLPDVRNQ ADVIY -
予測される分子量
60 kDa including tags -
領域
578 to 872 -
タグ
GST tag N-Terminus -
配列の追加情報
Genbank: NM_006343
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関連製品
特性
Our Abpromise guarantee covers the use of ab271471 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Flow Cytometry
SDS-PAGE
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol (glycerin, glycerine), 0.05% GlutathioneThis product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- c MER
- c mer proto oncogene tyrosine kinase
- c-mer
see all -
機能
In case of filovirus infection, seems to function as a cell entry factor. -
組織特異性
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. -
関連疾患
Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
画像
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Functional Studies - Recombinant Human MERTK protein (Tagged) (ab271471)
Specific activity of ab271471.
Specific activity ≥50 pmol/min/µg.
Assay was done in kinase buffer containing 1 mM DTT using Poly- (Glu4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min.
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SDS-PAGE - Recombinant Human MERTK protein (Tagged) (ab271471)SDS-PAGE analysis of ab271471.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab271471 は論文での使用が確認できていません。