Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Tags: GST tag N-Terminus
- Suitable for: Flow Cyt, SDS-PAGE
製品名Recombinant human MERTK protein (Active)
MERTK タンパク質・ペプチド 製品一覧
Specific activity ≥50 pmol/min/µg.
Assay was done in kinase buffer containing 1 mM DTT using Poly- (Glu4:Tyr) substrate (0.2 mg/ml) and 20 μM ATP. Reaction was done at 30°C for 45 min.
精製度>= 90 % SDS-PAGE.
発現系Baculovirus infected Sf9 cells
配列EDVVIDRNLL ILGKILGEGE FGSVMEGNLK QEDGTSLKVA VKTMKLDNSS QREIEEFLSE AACMKDFSHP NVIRLLGVCI EMSSQGIPKP MVILPFMKYG DLHTYLLYSR LETGPKHIPL QTLLKFMVDI ALGMEYLSNR NFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI AIESLADRVY TSKSDVWAFG VTMWEIATRG MTPYPGVQNH EMYDYLLHGH RLKQPEDCLD ELYEIMYSCW RTDPLDRPTF SVLRLQLEKL LESLPDVRNQ ADVIY
予測される分子量60 kDa including tags
領域578 to 872
タグGST tag N-Terminus
Our Abpromise guarantee covers the use of ab271471 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol (glycerin, glycerine), 0.05% Glutathione
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- c MER
- c mer proto oncogene tyrosine kinase
機能In case of filovirus infection, seems to function as a cell entry factor.
組織特異性Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
関連疾患Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.