Recombinant human KDM5B / PLU1 / Jarid1B protein (Active) (ab271567)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: >= 75% SDS-PAGE
- Active: Yes
- Tags: DDDDK tag N-Terminus, Avi tag N-Terminus
- Suitable for: SDS-PAGE, Functional Studies
製品の詳細
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製品名
Recombinant human KDM5B / PLU1 / Jarid1B protein (Active)
KDM5B / PLU1 / Jarid1B タンパク質・ペプチド 製品一覧 -
生理活性
Specific Activity: 0.11 pmol/min/µg. -
精製度
>= 75 % SDS-PAGE. -
発現系
Baculovirus infected Sf9 cells -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
予測される分子量
179 kDa -
領域
2 to 1544 -
タグ
DDDDK tag N-Terminus , Avi tag N-Terminus
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特性
Our Abpromise guarantee covers the use of ab271567 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Functional Studies
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol (glycerin, glycerine), 0.01% TCEP
80 µg/ml DDDDK peptideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
関連情報
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別名
- Cancer/testis antigen 31
- CT31
- Histone demethylase JARID1B
see all -
機能
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. -
組織特異性
Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). -
配列類似性
Belongs to the JARID1 histone demethylase family.
Contains 1 ARID domain.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 3 PHD-type zinc fingers. -
ドメイン
Both the JmjC domain and the JmjN domain are required for enzymatic activity.
The 2 first PHD-type zinc finger domains are required for transcription repression activity. -
細胞内局在
Nucleus. - Information by UniProt
画像
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Functional Studies - Recombinant human KDM5B / PLU1 / Jarid1B protein (Active) (ab271567)Specific activity of ab271567.
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SDS-PAGE - Recombinant human KDM5B / PLU1 / Jarid1B protein (Active) (ab271567)SDS-PAGE analysis of 2.3 µg ab271567.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
参考文献 (0)
ab271567 は論文での使用が確認できていません。
