Recombinant human DR4 protein (ab641)

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Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level: < 0.100 Eu/µg
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

製品の詳細

  • 製品名

    Recombinant human DR4 protein
    DR4 タンパク質・ペプチド 製品一覧

  • エンドトキシン・レベル

    < 0.100 Eu/µg

  • 発現系

    Escherichia coli

  • タンパク質長

    Full length protein

  • Animal free

    No

  • 由来

    Recombinant

    • 生物種

      Human

    • 配列

      SGTGAAAATP SKVWGSSAGR IEPRGGGRGA LPTSMGQHGP SARARAGRAP GPRPAREASP RLRVHKTFKF VVVGVLLQVV PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRSERPGA CNRCTEGVGY TNASQQLFAC LPCTACKSDE EERSPCTTTR NTACQCKPGT FRNDNSAEMC RKCSTGCPRG MVKVKDCTPW SDIECVHKES GNGHN

    • 予測される分子量

      23 kDa

関連製品

    特性

    Our Abpromise guarantee covers the use of ab641 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Functional Studies

      SDS-PAGE

    • 製品の状態

      Lyophilized

    • 備考

      The biological activity of this product was determined by its inhibitory effect of IL-8 production in human PBMC by Human sTRAIL/Apo2L. 95% inhibition (100ng/ml of sTRAIL/Apo2L) was reached using a concentration of 100ng/ml of sTRAIL Receptor-1.
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • 再構成
      RECONSTITUTE with 60ul sterile WATER.

    関連情報

    • 別名

      • Apo2
      • CD261
      • Cytotoxic TRAIL receptor
      • Death receptor 4
      • DR4
      • NF related apoptosis-inducing ligand receptor 1
      • TNF receptor superfamily member 10a
      • TNF-related apoptosis-inducing ligand receptor 1
      • TNFRSF10A
      • TR10A_HUMAN
      • TRAIL receptor 1
      • TRAIL-R1
      • TRAILR 1
      • TRAILR1
      • Tumor necrosis factor receptor superfamily member 10A
      • Tumor necrosis factor receptor superfamily member 10a variant 2
      • Tumor necrosis factor receptor superfamily, member 10a
      see all

    • 機能

      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

    • 組織特異性

      Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.

    • 配列類似性

      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (1)

    ab641 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab641 は 1 報の論文で使用されています。

    • Dai B  et al. WD Repeat Domain 5 Promotes Invasion, Metastasis and Tumor Growth in Glioma Through Up-Regulated Zinc Finger E-Box Binding Homeobox 1 Expression. Cancer Manag Res 12:3223-3235 (2020). PubMed: 32440219

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