製品の概要
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製品名Recombinant human DR4 protein
DR4 タンパク質・ペプチド 製品一覧 -
タンパク質長Full length protein
製品の詳細
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由来Recombinant
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由来Escherichia coli
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アミノ酸配列
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生物種Human
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配列SGTGAAAATP SKVWGSSAGR IEPRGGGRGA LPTSMGQHGP SARARAGRAP GPRPAREASP RLRVHKTFKF VVVGVLLQVV PSSAATIKLH DQSIGTQQWE HSPLGELCPP GSHRSERPGA CNRCTEGVGY TNASQQLFAC LPCTACKSDE EERSPCTTTR NTACQCKPGT FRNDNSAEMC RKCSTGCPRG MVKVKDCTPW SDIECVHKES GNGHN
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分子量23 kDa
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特性
Our Abpromise guarantee covers the use of ab641 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Functional Studies
SDS-PAGE
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エンドトキシン・レベル< 0.100 Eu/µg
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製品の状態Lyophilised
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備考The biological activity of this product was determined by its inhibitory effect of IL-8 production in human PBMC by Human sTRAIL/Apo2L. 95% inhibition (100ng/ml of sTRAIL/Apo2L) was reached using a concentration of 100ng/ml of sTRAIL Receptor-1.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
n/a
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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再構成RECONSTITUTE with 60ul sterile WATER.
関連情報
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別名
- Apo2
- CD261
- Cytotoxic TRAIL receptor
see all -
機能Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
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組織特異性Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
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配列類似性Contains 1 death domain.
Contains 3 TNFR-Cys repeats. -
細胞内局在Membrane.
- Information by UniProt
参考文献
ab641 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"