This product is an active protein and may elicit a biological response in vivo, handle with caution.
B cell CLL/lymphoma 1
BCL 1 oncogene
cell division protein kinase 6
cyclin D1 1
cyclin dependent kinase 6
G1 S specific cyclin D1
Serine threonine protein kinase PLSTIRE
CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors (1). The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein (2).
CCND1 is essential for the control of the cell cycle at the G1/S (start) transition
SDS-PAGE - Recombinant human CDK6 + CCND1 protein (ab84559)
Purity of CDK6 + CCND1 was determined to be >85% by densitometry. CDK6 approx. MW 40kDa and CCND1 approx. MW 61kDa.
Functional Studies - Recombinant human CDK6 + CCND1 protein (ab84559)
Specific activity of CDK6 + CCND1 was determined to be 9.3 nmol/min/mg as per activity assay protocol.
has not yet been referenced specifically in any publications.