Recombinant Human CDC5L protein (ab132350)
Key features and details
- Expression system: Wheat germ
- Suitable for: WB, SDS-PAGE, ELISA
製品の詳細
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製品名
Recombinant Human CDC5L protein -
発現系
Wheat germ -
アクセッション番号
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タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARW YEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHY EFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELE MLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQK KRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGE LRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAP QISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVAL RTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQ VVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNI NPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEK ELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSE VNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKG KTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHG ELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINR GHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELR TFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKS KF -
予測される分子量
119 kDa including tags -
領域
1 to 802
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab132350 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
Western blot
SDS-PAGE
ELISA
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製品の状態
Liquid -
Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
関連情報
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別名
- CDC5
- CDC5 cell division cycle 5-like (S. pombe)
- Cdc5 related protein
see all -
機能
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. -
組織特異性
Ubiquitously expressed in both fetal and adult tissues. -
関連疾患
A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2. -
配列類似性
Belongs to the CEF1 family.
Contains 2 HTH myb-type DNA-binding domains. -
翻訳後修飾
Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8. -
細胞内局在
Nucleus. Nucleus speckle. Cytoplasm. May shuttle between cytoplasm and nucleus. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab132350 は論文での使用が確認できていません。