Recombinant Human CD32B protein (Tagged) (ab269989)

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SDS-PAGE - Recombinant Human CD32B protein (Tagged) (ab269989)
  • Western blot - Recombinant Human CD32B protein (Tagged) (ab269989)

Key features and details

  • Expression system: HEK 293 cells
  • Tags: His tag C-Terminus, Avi tag C-Terminus
  • Suitable for: WB, SDS-PAGE

製品の詳細

  • 製品名

    Recombinant Human CD32B protein (Tagged)
    CD32B タンパク質・ペプチド 製品一覧

  • 精製度

    >90% by SDS-PAGE.

  • 発現系

    HEK 293 cells

  • アクセッション番号

    P31994

  • タンパク質長

    Protein fragment

  • Animal free

    No

  • 由来

    Recombinant

    • 生物種

      Human

    • 配列

      APPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHT QPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEG ETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYH CTGNIGYTLYSSKPVTITVQAP

    • 予測される分子量

      23 kDa including tags

    • 領域

      46 to 217

    • タグ

      His tag C-Terminus , Avi tag C-Terminus

    • 配列の追加情報

      NM_004001.4. C-terminal Avi-His-Tag.

特性

Our Abpromise guarantee covers the use of ab269989 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 製品の状態

    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol (glycerin, glycerine), 0.13% Sodium phosphate

関連情報

  • 別名

    • CD32
    • CD32 antigen
    • CD32B
    • CDw32
    • Fc fragment of IgG, low affinity II, receptor for (CD32)
    • Fc fragment of IgG, low affinity IIb, receptor
    • Fc fragment of IgG, low affinity IIb, receptor (CD32)
    • Fc fragment of IgG, low affinity IIb, receptor for
    • Fc fragment of IgG, low affinity IIb, receptor for (CD32)
    • Fc gamma receptor IIB
    • Fc gamma RII
    • Fc gamma RIIB
    • Fc-gamma RII
    • Fc-gamma RII-b
    • Fc-gamma-RIIb
    • FCG2
    • FCG2B_HUMAN
    • Fcgr2
    • FCGR2B
    • FCRII
    • FcRII-b
    • IGFR2
    • IgG Fc receptor II beta
    • IgG Fc receptor II-b
    • Low affinity immunoglobulin gamma Fc region receptor II
    • Low affinity immunoglobulin gamma Fc region receptor II-b
    • Ly-17
    • Lym 1
    • Lymphocyte antigen 17
    see all

  • 機能

    Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

  • 組織特異性

    Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

  • 関連疾患

    Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.

  • 配列類似性

    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

  • ドメイン

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

  • 細胞内局在

    Cell membrane.
  • Information by UniProt

画像

  • SDS-PAGE - Recombinant Human CD32B protein (Tagged) (ab269989)
    SDS-PAGE - Recombinant Human CD32B protein (Tagged) (ab269989)

    SDS-PAGE analysis of 5 μg ab269989. 4-20% gel with Coomasie staining.

  • Western blot - Recombinant Human CD32B protein (Tagged) (ab269989)
    Western blot - Recombinant Human CD32B protein (Tagged) (ab269989)

    Western blot analysis of ab269989.

プロトコール

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

参考文献 (0)

ab269989 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab269989 は論文での使用が確認できていません。

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