Recombinant human BCMA protein (Fc Chimera Active) (ab270565)

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Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 95% SDS-PAGE
  • Endotoxin level: < 0.010 Eu/µg
  • Active: Yes
  • Tags: Fc tag C-Terminus
  • Suitable for: Functional Studies, SDS-PAGE

製品の詳細

  • 製品名

    Recombinant human BCMA protein (Fc Chimera Active)
    BCMA タンパク質・ペプチド 製品一覧

  • 生理活性

    Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF and APRIL-mediated B cell activation.

  • 精製度

    >= 95 % SDS-PAGE.

  • エンドトキシン・レベル

    < 0.010 Eu/µg

  • 発現系

    HEK 293 cells

  • アクセッション番号

    Q02223

  • タンパク質長

    Protein fragment

  • Animal free

    No

  • 由来

    Recombinant

    • 生物種

      Human

    • 配列

      MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVK GTNAILWTCL

    • 分子量情報

      ~40kDa by SDS-PAGE

    • 領域

      2 to 54

    • タグ

      Fc tag C-Terminus

    • 配列の追加情報

      Extracellular domain

関連製品

    特性

    Our Abpromise guarantee covers the use of ab270565 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • アプリケーション

      Functional Studies

      SDS-PAGE

    • 製品の状態

      Lyophilized
    • Concentration information loading...

    前処理および保存

    • 保存方法および安定性

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle.

      Constituent: PBS

      Buffer lyophilized from

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • 再構成
      Reconstitute with 50µl sterile water. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.

    関連情報

    • 別名

      • B cell maturation antigen
      • B cell maturation factor
      • B cell maturation protein
      • B-cell maturation protein
      • BCM
      • BCMA
      • CD269
      • CD269 antigen
      • TNFRSF17
      • TNR17_HUMAN
      • Tumor necrosis factor receptor superfamily member 17
      see all

    • 機能

      Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

    • 組織特異性

      Expressed in mature B-cells, but not in T-cells or monocytes.

    • 関連疾患

      Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

    • 配列類似性

      Contains 1 TNFR-Cys repeat.

    • 細胞内局在

      Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
    • Information by UniProt

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab270565 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab270565 は論文での使用が確認できていません。

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