Recombinant Cynomolgus monkey SIRP alpha protein (Tagged) (Biotin) (ab271742)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Tags: His tag C-Terminus, Avi tag C-Terminus
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Cynomolgus monkey SIRP alpha protein (Tagged) (Biotin)
SIRP alpha タンパク質・ペプチド 製品一覧 -
精製度
>= 90 % SDS-PAGE. -
発現系
HEK 293 cells -
アクセッション番号
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タンパク質長
Protein fragment -
Animal free
No -
由来
Recombinant -
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生物種
Cynomolgus monkey -
配列
EEELQVIQPE KSVSVAAGDS ATLNCTVSSL IPVGPIQWFR GAGPGRELIY NLKEGHFPRV TAVSDPTKRN NMDFSIRISN ITPADAGTYY CVKFRKGSPD VELKSGAGTE LSVRAKPSAP VVSGPAVRAT AEHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDVQTNVDPA GKSVSYSIRS TARVLLTRRD VHSQVICEVA HVTLQGDPLR GTANLSEAIR VPPFLEVTQQ SMRADNQVNV TCQVTKFYPQ RLQLTWLENG NVSRTEMASA LPENKDGTYN WTSWLLVNVS AHRDDVKLTC QVEHDGQPAV NKSFSVKVSA HPKEQGSNTA AENTGTNERN -
予測される分子量
42 kDa -
領域
31 to 370 -
タグ
His tag C-Terminus , Avi tag C-Terminus
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標識
Biotin
関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab271742 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Liquid -
備考
Enzymatically biotin-labeled using Avi-tag™ technology
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle. Store In the Dark.
pH: 7.40
Constituents: 0.13% Sodium phosphate, 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol (glycerin, glycerine)
関連情報
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別名
- Signal regulatory protein alpha type 1
- Bit
- Brain Ig like molecule with tyrosine based activation motifs
see all -
機能
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. -
組織特異性
Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. -
配列類似性
Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻訳後修飾
N-glycosylated.
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11. -
細胞内局在
Membrane. - Information by UniProt
画像
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SDS-PAGE - Recombinant Cynomolgus monkey SIRP alpha protein (Tagged) (Biotin) (ab271742)
SDS-PAGE analysis of 4 µg ab271742.
This protein is heavily glycosylated, resulting in apparent higher molecular weight.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab271742 は論文での使用が確認できていません。