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ab89 は 35 報の論文で使用されています。

  • Meng X  et al. DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma. EBioMedicine 41:185-199 (2019). PubMed: 30773478
  • Ho V  et al. Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis. BMC Cancer 18:869 (2018). PubMed: 30176843
  • Li Z  et al. Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair. Cell Res 28:756-770 (2018). PubMed: 29844578
  • Luo M  et al. Unrepaired DNA damage in macrophages causes elevation of particulate matter- induced airway inflammatory response. Aging (Albany NY) 10:549-560 (2018). PubMed: 29661984
  • Hung PJ  et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell 71:332-342.e8 (2018). PubMed: 30017584
  • Brandt S  et al. Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer. BMC Cancer 17:44 (2017). PubMed: 28073364
  • Lou J  et al. AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway. Nat Commun 8:985 (2017). PubMed: 29042561
  • Tsukagoshi M  et al. Overexpression of karyopherin-a2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins. Oncotarget 8:42159-42172 (2017). PubMed: 28178675
  • Hollingworth R  et al. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol 91:N/A (2017). PubMed: 28855246
  • Ho V  et al. Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival. Cancers (Basel) 9:N/A (2017). PubMed: 29189711
  • Chang L  et al. Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy. BMC Cancer 16:190 (2016). WB, ICC/IF ; Human . PubMed: 26951044
  • Petroni M  et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ 23:197-206 (2016). WB ; Human . PubMed: 26068589
  • Davies OR  et al. CtIP tetramer assembly is required for DNA-end resection and repair. Nat Struct Mol Biol 22:150-157 (2015). PubMed: 25558984
  • Clynes D  et al. Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX. Nat Commun 6:7538 (2015). IP, ICC/IF ; Human . PubMed: 26143912
  • Millet R  et al. Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1. J Virol 89:6824-34 (2015). PubMed: 25903339
  • Al-Ahmadie H  et al. Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy. Cancer Discov 4:1014-21 (2014). PubMed: 24934408
  • Porro A  et al. TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres. Cell Rep 6:765-76 (2014). PubMed: 24529708
  • Clynes D  et al. ATRX dysfunction induces replication defects in primary mouse cells. PLoS One 9:e92915 (2014). IP, IF ; Mouse . PubMed: 24651726
  • Koppensteiner R  et al. Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro. PLoS One 9:e100041 (2014). IHC-P ; Human . PubMed: 24927325
  • Schröder-Heurich B  et al. Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line. BMC Cancer 14:434 (2014). WB ; Human . PubMed: 24928521
  • Schröder-Heurich B  et al. Protective role of RAD50 on chromatin bridges during abnormal cytokinesis. FASEB J 28:1331-41 (2014). PubMed: 24344331
  • Green H  et al. Pegylated liposomal doxorubicin as first-line monotherapy in elderly women with locally advanced or metastatic breast cancer: Novel treatment predictive factors identified. Cancer Lett 313:145-53 (2011). IHC-P ; Human . PubMed: 22056077
  • Nicolas A  et al. Identification of rep-associated factors in herpes simplex virus type 1-induced adeno-associated virus type 2 replication compartments. J Virol 84:8871-87 (2010). IF . PubMed: 20573815
  • Choudhury A  et al. MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer. Cancer Res 70:7017-7026 (2010). IHC-P ; Human . PubMed: 20843819
  • Kadaja M  et al. Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses. PLoS Pathog 5:e1000397 (2009). ICC/IF ; Human . PubMed: 19390600
  • Huang J  et al. SOSS complexes participate in the maintenance of genomic stability. Mol Cell 35:384-93 (2009). WB ; Human . PubMed: 19683501
  • Djuzenova CS  et al. Differential response of human glioblastoma cell lines to combined camptothecin and ionizing radiation treatment. Cancer Biol Ther 7:364-73 (2008). Human . PubMed: 18075304
  • Tommiska J  et al. Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer 118:2911-6 (2006). PubMed: 16385572
  • Fernet M  et al. Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Hum Mol Genet 14:307-18 (2005). PubMed: 15574463
  • Honrado E  et al. Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors. J Clin Oncol 23:7503-11 (2005). IHC-P ; Human . PubMed: 16234517
  • Djuzenova C  et al. Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients. Br J Cancer 90:2356-63 (2004). PubMed: 15150571
  • Uziel T  et al. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 22:5612-21 (2003). PubMed: 14532133
  • Xu X & Stern DF NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J 17:1842-8 (2003). PubMed: 14519663
  • Stracker TH  et al. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 418:348-52 (2002). PubMed: 12124628
  • Tauchi H  et al. The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity. J Biol Chem 276:12-5 (2001). PubMed: 11062235

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