Key features and details
- Rat monoclonal [KT80] to RAB11B
- Reacts with: Mouse
- Isotype: IgG2a
- 倫理基準に準拠 - アニマル・フリーの生産
製品名Anti-RAB11B antibody [KT80]
RAB11B 一次抗体 製品一覧
製品の詳細Rat monoclonal [KT80] to RAB11B
Fusion protein corresponding to Mouse Rab11.
Database link: P46638
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
バッファーPreservative: 0.1% Sodium azide
Concentration information loading...
精製度Protein G purified
特記事項（精製）ab95375 is purified from culture supernatants using a Protein G column.
機能The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
配列類似性Belongs to the small GTPase superfamily. Rab family.
翻訳後修飾Citrullinated by PADI4.
細胞内局在Recycling endosome membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasmic vesicle, phagosome membrane. Recruited to phagosomes containing S.aureus.
- Information by UniProt
- GTP-binding protein ypt3 antibody
- H YPT3 antibody
- RAB11B antibody
ab95375 は 6 報の論文で使用されています。
- Sun J et al. PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. Sci Rep 10:9824 (2020). PubMed: 32555345
- Che Y et al. KRAS regulation by small non-coding RNAs and SNARE proteins. Nat Commun 10:5118 (2019). PubMed: 31712554
- Scavuzzo MA et al. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep 25:3811-3827.e7 (2018). PubMed: 30590051
- Del Cid-Pellitero E et al. Homeostatic Changes in GABA and Glutamate Receptors on Excitatory Cortical Neurons during Sleep Deprivation and Recovery. Front Syst Neurosci 11:17 (2017). PubMed: 28408870
- Tjondrokoesoemo A et al. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet 25:1192-202 (2016). PubMed: 26744329
- Vanhoutte D et al. Thrombospondin expression in myofibers stabilizes muscle membranes. Elife 5:N/A (2016). WB ; Mouse . PubMed: 27669143
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