Anti-Rab11A 抗体 (ab2921)

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Key features and details

  • Goat polyclonal to Rab11A
  • Suitable for: WB
  • Reacts with: Mouse
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-Rab11A antibody
    Rab11A 一次抗体 製品一覧

  • 製品の詳細

    Goat polyclonal to Rab11A

  • 由来種

    Goat

  • アプリケーション

    適用あり: WBmore details

  • 種交差性

    交差種: Mouse
    交差が予測される動物種: Human

  • 免疫原

    Synthetic peptide:

    TENKPKVQCCQNI

    , corresponding to C terminal amino acids 204-216 of Human Rab11A.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • ポジティブ･コントロール

    • Mouse Heart lysate

  • 特記事項

    Principal Names – RAB11A; YL8; RAB11A, member RAS oncogene family; RAB 11A, member oncogene family Official Gene Symbol - RAB11A GenBank Accession Number – NP_004654 LocusLink ID - 55072 (human) Gene Ontology terms - RAB small monomeric GTPase

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 25-28 kDa (predicted molecular weight: 25 kDa).

A 1 hour primary incubation is recommended for this product. Approx 25-28kDa band seen in Mouse Heart lysate.

ターゲット情報

  • 機能

    Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.

  • 配列類似性

    Belongs to the small GTPase superfamily. Rab family.

  • 細胞内局在

    Cell membrane. Recycling endosome membrane. Cleavage furrow. Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
  • Information by UniProt

  • 参照データベース

    • 別名

      • MGC1490 antibody
      • Rab 11 antibody
      • Rab 11A antibody
      • RAB 11A, member oncogene family antibody
      • Rab-11 antibody
      • RAB11 A antibody
      • RAB11 antibody
      • Rab11a antibody
      • RAB11A member RAS oncogene family antibody
      • Ras related protein Rab 11A antibody
      • Ras related protein Rab11A antibody
      • Ras-related protein Rab-11A antibody
      • RB11A_HUMAN antibody
      • YL 8 antibody
      • YL8 antibody
      see all

    参考文献 (1)

    ab2921 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab2921 は 1 報の論文で使用されています。

    • Wrenn SM  et al. Avian lungs: A novel scaffold for lung bioengineering. PLoS One 13:e0198956 (2018). PubMed: 29949597

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